Comments on: Why can being obese lead to Type 2 diabetes? http://diabetesanddiet.net/diabetes-and-fats/why-can-being-obese-lead-to-type-2-diabetes Best Information on Diabetes and Diet Sat, 30 Jul 2011 05:01:59 +0000 hourly 1 http://wordpress.org/?v=3.2.1 By: zygote222 http://diabetesanddiet.net/diabetes-and-fats/why-can-being-obese-lead-to-type-2-diabetes/comment-page-1#comment-1631 zygote222 Thu, 29 Oct 2009 14:07:59 +0000 http://diabetesanddiet.net/diabetes-and-fats/why-can-being-obese-lead-to-type-2-diabetes#comment-1631 The short answer is that no one knows exactly why obesity is a risk factor for type 2 diabetes. However, your explanation - that fat particles "interfere with the normal functions of the pancreas" - is not consistent with what we do know. Type 2 diabetics typically have normal, or near normal, levels of insulin but are unable to utilize the insulin effectively. So it's not the pancreas that is the problem. <br><b>References : </b><br> The short answer is that no one knows exactly why obesity is a risk factor for type 2 diabetes. However, your explanation – that fat particles "interfere with the normal functions of the pancreas" – is not consistent with what we do know. Type 2 diabetics typically have normal, or near normal, levels of insulin but are unable to utilize the insulin effectively. So it’s not the pancreas that is the problem.
References :

]]> By: Guru http://diabetesanddiet.net/diabetes-and-fats/why-can-being-obese-lead-to-type-2-diabetes/comment-page-1#comment-1630 Guru Thu, 29 Oct 2009 13:38:59 +0000 http://diabetesanddiet.net/diabetes-and-fats/why-can-being-obese-lead-to-type-2-diabetes#comment-1630 Obesity is a major factor in the increase in diabetes. Type 2 diabetes something is interfering with the action of the IRS proteins. What might it be? An estimated 80% of those who develop type 2 diabetes are obese, a tantalizing clue. Your body manufactures insulin after a meal as a way to alert cells that higher levels of glucose are coming soon. The insulin signal attaches to special receptors on the cell surfaces, which respond by causing the cell to turn on its glucose-transporting machinery. Individuals who suffer from type 2 diabetes have normal or even elevated levels of insulin in their blood, and normal insulin receptors, but for some reason the binding of insulin to their cell receptors does not turn on the glucose-transporting machinery like it is supposed to do. For 30 years researchers have been trying to figure out why not. How does insulin act to turn on a normal cell’s glucose transporting machinery? Proteins called IRS proteins (the names refer not to taxes, but to insulin receptor substrate) snuggle up against the insulin receptor inside the cell. When insulin attaches to the receptor protein, the receptor responds by adding a chemical called a phosphate group onto the IRS molecules.<br><b>References : </b><br>http://www.diabetesindetail.com/Diabetes_and_Weight_Loss.html Obesity is a major factor in the increase in diabetes. Type 2 diabetes something is interfering with the action of the IRS proteins. What might it be? An estimated 80% of those who develop type 2 diabetes are obese, a tantalizing clue.

Your body manufactures insulin after a meal as a way to alert cells that higher levels of glucose are coming soon. The insulin signal attaches to special receptors on the cell surfaces, which respond by causing the cell to turn on its glucose-transporting machinery.

Individuals who suffer from type 2 diabetes have normal or even elevated levels of insulin in their blood, and normal insulin receptors, but for some reason the binding of insulin to their cell receptors does not turn on the glucose-transporting machinery like it is supposed to do. For 30 years researchers have been trying to figure out why not.

How does insulin act to turn on a normal cell’s glucose transporting machinery? Proteins called IRS proteins (the names refer not to taxes, but to insulin receptor substrate) snuggle up against the insulin receptor inside the cell. When insulin attaches to the receptor protein, the receptor responds by adding a chemical called a phosphate group onto the IRS molecules.
References :
http://www.diabetesindetail.com/Diabetes_and_Weight_Loss.html

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