Why can being obese lead to Type 2 diabetes?
Looks like the process related to obesity and diabetes is that the oventum’s overload of excess fat from obesity creates plaques like cholesterol. Those plaques eventually burst and go right into the pancreas, which controls blood sugar. The detonated fat particles then interfere with normal functions of the pancreas, causing an severe inflammatory response that leads to chronic hyperglycemia or hypoglycemia as the inflammatory damage in the pancreas means that blood sugar is not going to be normal anymore.
Obesity is a major factor in the increase in diabetes. Type 2 diabetes something is interfering with the action of the IRS proteins. What might it be? An estimated 80% of those who develop type 2 diabetes are obese, a tantalizing clue.
Your body manufactures insulin after a meal as a way to alert cells that higher levels of glucose are coming soon. The insulin signal attaches to special receptors on the cell surfaces, which respond by causing the cell to turn on its glucose-transporting machinery.
Individuals who suffer from type 2 diabetes have normal or even elevated levels of insulin in their blood, and normal insulin receptors, but for some reason the binding of insulin to their cell receptors does not turn on the glucose-transporting machinery like it is supposed to do. For 30 years researchers have been trying to figure out why not.
How does insulin act to turn on a normal cell’s glucose transporting machinery? Proteins called IRS proteins (the names refer not to taxes, but to insulin receptor substrate) snuggle up against the insulin receptor inside the cell. When insulin attaches to the receptor protein, the receptor responds by adding a chemical called a phosphate group onto the IRS molecules.
admin on October 29th 2009 in Diabetes and Fats
Guru responded on 29 Oct 2009 at 8:38 am #
Obesity is a major factor in the increase in diabetes. Type 2 diabetes something is interfering with the action of the IRS proteins. What might it be? An estimated 80% of those who develop type 2 diabetes are obese, a tantalizing clue.
Your body manufactures insulin after a meal as a way to alert cells that higher levels of glucose are coming soon. The insulin signal attaches to special receptors on the cell surfaces, which respond by causing the cell to turn on its glucose-transporting machinery.
Individuals who suffer from type 2 diabetes have normal or even elevated levels of insulin in their blood, and normal insulin receptors, but for some reason the binding of insulin to their cell receptors does not turn on the glucose-transporting machinery like it is supposed to do. For 30 years researchers have been trying to figure out why not.
How does insulin act to turn on a normal cell’s glucose transporting machinery? Proteins called IRS proteins (the names refer not to taxes, but to insulin receptor substrate) snuggle up against the insulin receptor inside the cell. When insulin attaches to the receptor protein, the receptor responds by adding a chemical called a phosphate group onto the IRS molecules.
References :
http://www.diabetesindetail.com/Diabetes_and_Weight_Loss.html
zygote222 responded on 29 Oct 2009 at 9:07 am #
The short answer is that no one knows exactly why obesity is a risk factor for type 2 diabetes. However, your explanation – that fat particles "interfere with the normal functions of the pancreas" – is not consistent with what we do know. Type 2 diabetics typically have normal, or near normal, levels of insulin but are unable to utilize the insulin effectively. So it’s not the pancreas that is the problem.
References :